Symbol
Name
ID

C9orf72
C9orf72, member of C9orf72-SMCR8 complex
MGI:1920455

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

enlarged spleen

increased spleen weight

increased neutrophil cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

decreased lymphocyte cell number

increased leukocyte cell number

abnormal lymphocyte morphology

abnormal spleen morphology

increased splenocyte number

increased IgG level

increased IgM level

abnormal macrophage physiology

abnormal microglial cell physiology

abnormal circulating cytokine level

abnormal circulating interleukin level

decreased circulating interleukin-2 level

abnormal celiac lymph node morphology

abnormal lymph node cell ratio

enlarged lymph nodes

abnormal cervical lymph node morphology

enlarged cervical lymph nodes

increased susceptibility to autoimmune disorder

increased autoantibody level

increased anti-double stranded DNA antibody level

brain inflammation

liver inflammation

dermatitis

Availability

Mouse Genotype

C9orf72^em1Eggn/C9orf72^em1Eggn

C9orf72^em5Lutzy/C9orf72^em5Lutzy

C9orf72^{tm1.1(KOMP)Mbp}/C9orf72^{tm1.1(KOMP)Mbp}

C9orf72^tm1.1Eggn/C9orf72^tm1.1Eggn

C9orf72^tm1Eggn/C9orf72^tm1Eggn

C9orf72^tm1Lagi/C9orf72^tm1Lagi

C9orf72^tm1.1Eggn/C9orf72⁺

C9orf72^tm1Eggn/C9orf72⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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